The Slovak Radio Symphony Orchestra (SOSR) was established in 1929 as the first professional symphony orchestra in Slovakia. The Czech conductor František Dyk was then appointed to be the official leader of the Orchestra. The beginnings of SOSR are connected with the intense activity of Alexander Moyzes, who contributed to the gradual improvement and enlargement of the Orchestra. Over the years the Orchestra was led by many outstanding personalities including Kornel Schimpl, František Babušek, Krešimir Baranović, Ľudovít Rajter, Richard Týnský, Ladislav Slovák, Bystrík Režucha, Otakar Trhlík, Ondrej Lenárd, Róbert Stankovský, Charles Olivieri Munroe, Oliver Dohnányi and Mario Košik. Since 2018 the Orchestra is led by chief conductor Peter Valentovič, the second conductor of the Orchestra is Adrian Kokoš.
SOSR has recorded countless recordings for publishers such as Opus, Supraphon, Naxos, Marco Polo, Arte Nova and ranks among orchestras with the biggest number of released audio media in the world. One of recent important activities of SOSR includes for instance the premiere recording of the opera by Ermanno Wolf–Ferrari: The Jewels of the Madonna (I gioielli della Madonna) for the Naxos publishing house. Moreover, SOSR regularly participates in recording music for Slovak movies. The Orchestra performs with renowned guest conductors such as Ch. Mackerras, N. Järvi, K. Trevor, A. Paris, F. Haider, A. Mogrelia, D. Porcelijn, V. Spivakov, P. Altrichter, Y. Kamdzhalov and others. Many excellent soloists from Slovakia and abroad have already performed with the Orchestra including Anna Netrebko, Yusif Eyvazov, Boris Berezovskij, Edita Gruberová, Adriana Kučerová, Štefan Kocán, Pavol Bršlík, Daniel Ottensamer, Dana Ciocarlie, Alena Baeva, Andrey Yaroshinsky, Jiří Bárta, Milan Paľa, Dalibor Karvay and others. The Orchestra regularly performs at music festivals in Slovakia such as the Bratislava Music Festival, New Slovak Music Festival, Melos-Étos, Allegretto Žilina or Radio_Head Awards Festival. SOSR is also welcome at concert stages abroad and appeared as a guest for instance in Austria, Germany, Hungary, Spain or Japan. It performed several times at the prestigious Viennese Musikverein, in the Philharmonie in Essen, Philharmonie in Cologne and others. In the years 2016 and 2017 SOSR participated in opera productions at the St. Margarethen Opera Festival.    
The Slovak Radio Symphony Orchestra specializes in the repertory of classicism and romanticism as well as in the music of the 20th and 21st century, with particular focus on presentation of works by Slovak composers, whereby many of them are premièred.